This is a list of episodes for the fourth season of the American sitcom The Big Bang Theory, which is scheduled to begin airing on CBS beginning September 23, 2010.
| No. | Episode | Air Date | ||
| 1 | The Robotic Manipulation | 9/23/2010 | ||
| 2 | The Cruciferous Vegetable Amplification | 9/30/2010 | ||
| 3 | The Zazzy Substitution | 10/7/2010 | ||
| 4 | The Hot Troll Deviation | 10/14/2010 | ||
| 5 | The Desperation Emanation | 10/21/2010 | ||
| 6 | The Irish Pub Formulation | 10/28/2010 | ||
| 7 | The Apology Insufficiency | 11/4/2010 | ||
| 8 | The 21-Second Excitation | 11/11/2010 | ||
| 9 | The Boyfriend Complexity | 11/18/2010 | ||
| 10 | The Alien Parasite Hypothesis | 12/9/2010 | ||
| 11 | The Justice League Recombination | 12/16/2010 | ||
| 12 | The Bus Pants Utilization | 1/6/2011 | ||
| 13 | The Love Car Displacement | 1/20/2011 | ||
| 14 | The Thespian Catalyst | 2/3/2011 | ||
| 15 | The Benefactor Factor | 2/10/2011 | ||
| 16 | The Cohabitation Formulation | 2/17/2011 | ||
| 17 | The Toast Derivation | 2/24/2011 | ||
| 18 | The Prestidigitation Approximation | 3/10/2011 | ||
| 19 | The Zarnecki Incursion | 3/31/2011 | ||
| 20 | The Herb Garden Germination | 4/7/2011 | ||
| 21 | The Agreement Dissection | 4/28/2011 | ||
| 22 | The Wildebeest Implementation | 5/5/2011 | ||
| 23 | The Engagement Reaction | 5/12/2011 | ||
| 24 | The Roommate Transmogrification | 5/19/2011 | ||
| 25 | The Roommate Transmogrification | 5/19/2011 |
